反应详情

120 g (743 mmol) of 5-chloromethylisoxazole-3-carboxylic acid together with 500 ml of thionyl chloride and 2 drops of pyridine were refluxed for 10 hours, subsequently concentrated in vacuo and then distilled at 20 torr. The product distilled at 125-1330C. 78 g resulted (58% of theory)

1. concentrationsubsequently concentrated in vacuo
2. distillationdistilled at 20 torr
3. distillationThe product distilled at 125-1330C
4. custom78 g resulted (58% of theory)