Ammonia → HCID 21866458, compound

HRID 1582913Notes

Reaction equation

HRID 1582913 reaction equation
[C:1]([NH:8][CH2:9][C:10]1[S:11][C:12]([C:19]([O:21]CC)=O)=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH3:24]>CO>[C:1]([NH:8][CH2:9][C:10]1[S:11][C:12]([C:19]([NH2:24])=[O:21])=[C:13]([C:15]([F:18])([F:17])[F:16])[N:14]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21866504HCID 21866504, compound

Product 1

HCID 21866458HCID 21866458, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 2-(N-BOC-aminomethyl)-4-trifluoromethylthiazole-5-carboxylate [sic] (15 g, 42.33 mol) was dissolved in methanol. Ammonia was passed into the solution at room temperature until all of the ester had been converted into the carboxamide. The solvent was removed on a rotary evaporator and the crude product was purified by flash chromatography. Yield: 4.6 g (14.14 mmol, 33%).

Workup

  1. customwas passed into the solution at room temperature
  2. customThe solvent was removed on a rotary evaporator
  3. customthe crude product was purified by flash chromatography

Sources & evidence

ORD record
ord-2677d1a198814c229a1afca3044da6b2
Source dataset
uspto-grants-2004_05
Patent number
US06740647B1

Reaction notes

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