HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile → 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile | HCID 14173860 | — |
| Reactant | 5-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22560012 | — |
| Reactant | 4-(azidomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22715993 | — |
| Product | 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile | HCID 22715996 | — |
Reaction Steps
Starting from 5-Cyano-1-methylpyrrole-3-carbaldehyde; 4-aminomethyl-1-methylpyrrole-2-carbonitrile was synthesized analogously to the synthesis of 5-aminomethyl-1-methylpyrrole-2-carbonitrile. However, the 4-azidomethyl-1-methylpyrrole-2-carbonitrile was advantageously reduced in a Staudinger reaction (see S. Nagarajan et al. J. Org. Chem. 1987, 52, 5044-6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06740647B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-5eca5078d26e4e588ad1fe1f3b2ff332 |
| Source note | uspto-grants-2004_05 |