HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Homophthalic anhydride | HCID 12801 | — |
| Reactant | 3-(3-Chlorobenzoyl)-2-ethylamino-6-methylpyridine | HCID 11054902 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate | HCID 12991197 | — |
Reaction Steps
After the reaction of 3-(3-chlorobenzoyl)-2-ethylamino-6-methylpyridine with isochroman-1,3-dione (75%) under heating, the compound obtained by usual work-up was reacted with methyl iodide in 2-butanone in the presence of potassium carbonate. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate as a yellow solid. MS: 433.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06740662B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-a612e152cc634790bb966fa1e53ed09b |
| Source note | uspto-grants-2004_05 |