Diisopropylethylamine → HCID 178462948, compound

Participants

Reaction Steps

To a 15 ml 1,4-dioxane solution containing 314 mg of 3-(2-aminoethyl)-4-(3-chlorophenyl)-1-ethyl-7-methyl-1,8-naphthyridin-2(1H)-one were added 404 mg of 1-amidinopyrazole monohydrochloride and 0.48 ml of diisopropylethylamine, followed by stirring for 122 hours. The reaction solution was evaporated, the resulting solid was removed by filtration, and the solid was further washed with chloroform. The combine filtrate and washings were concentrated and the residue was purified by a silica gel column chromatography (chloroform-methanol-aqueous ammonia). The resulting oily substance was dissolved in 5 ml of ethanol, and 0.5 ml of 4M hydrogen chloride-ethyl acetate and acetonitrile were added thereto successively. The solvent was evaporated to obtain 347 mg of 4-(3-chlorophenyl)-1-ethyl-3-(2-guanidinoethyl)-7-methyl-1,8-naphthyridin-2(1H)-one monohydrochloride monohydrate as a colorless solid.

Provenance & Evidence