HuagongsheHuagongshe Chemistry Print Report · For research reference only
benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride → HCID 53839178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | benzyl (2R)-pyrrolidine-2-carboxylate hydrochloride | HCID 22827650 | — |
| Reactant | 2,6-Pyridinediacetic acid | HCID 23422430 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | HCID 53839178 | HCID 53839178 | 8% |
Reaction Steps
Using General Procedure A with 9.7 g (40 mmol) D-Proline benzyl ester hydrochloride and 3.9 g (20 mmol) (6-carboxymethyl-pyridin-2-yl)-acetic acid afforded, after flash chromatography (gradient: 0-10% MeOH/EtOAc), 890 mg (8%) of the title compound as a yellow oil. MS m/e (%): 570 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06740760B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-365ca30029904680a1efc916adee5853 |
| Source note | uspto-grants-2004_05 |