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HRID1583198

反应详情

EQUATION

反应方程式

HRID 1583198 的结构方程式

REACTANTS

反应物

2
结构：COc1ccc(CN)cc1OC
HCID79832

3,4-Dimethoxybenzylamine

C9H13NO2

结构：C=CC(=O)N1CCC[C@@H]1C(=O)OC(C)(C)C
HCID54536265

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(CN(CCC(=O)N2CCC[C@@H]2C(=O)OC(C)(C)C)CCC(=O)N2CCC[C@@H]2C(=O)OC(C)(C)C)cc1OC
HCID53912992

未命名化合物

收率 10.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

A solution of 1.0 g (4.44 mmol) (R)-1-acryloyl-pyrrolidine-2-carboxylic acid tert-butyl ester and 0.33 ml (2.22 mmol) veratrylamine in 25 ml acetonitrile was stirred for 16 h at 80° C. Concentration in vacuo and flash chromatography (gradient: 0-10% MeOH in EtOAc) afforded 150 mg (10%) of the title compound as a light brown oil.

WORKUP

后处理

  1. concentrationConcentration in vacuo and flash chromatography (gradient: 0-10% MeOH in EtOAc)