Pyridine → HCID 178444373, compound

HRID 1583238Notes

Reaction equation

HRID 1583238 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:11]=[C:10]([C@H:12]2[CH2:17][CH2:16][C@H:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:14][CH2:13]2)[CH:9]=[C:8]([F:23])[C:7]=1[OH:24].N1C=CC=CC=1>C1(C)C=CC=CC=1>[C:1]([O:24][C:7]1[C:6]([F:5])=[CH:11][C:10]([C@H:12]2[CH2:13][CH2:14][C@H:15]([CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])[CH2:16][CH2:17]2)=[CH:9][C:8]=1[F:23])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 6367Acetyl chlorideHCID 178444374HCID 178444374, compound

Product 1

HCID 178444373HCID 178444373, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

8 g of acetyl chloride is added to a solution of 28.2 g of 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-phenol and 20 ml of pyridine in 300 ml of toluene, and the mixture is heated at 80° for 1 hour. Cooling and working up in the usual manner gives 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-phenyl acetate.

Workup

  1. temperaturethe mixture is heated at 80° for 1 hour
  2. temperatureCooling

Sources & evidence

ORD record
ord-ae0b1b2887e84ca9b598de8476083f94
Source dataset
uspto-grants-1985_11
Patent number
US04551264

Reaction notes

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