Water → HCID 178444368, compound

HRID 1583239Notes

Reaction equation

HRID 1583239 reaction equation
[F:1][C:2]1[CH:9]=[C:8]([C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:12][CH2:11]2)[CH:7]=[C:6]([F:21])[C:3]=1[C:4]#N.[OH-:22].[K+].[OH2:24]>C(O)C>[F:1][C:2]1[CH:9]=[C:8]([C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH2:12][CH2:11]2)[CH:7]=[C:6]([F:21])[C:3]=1[C:4]([OH:24])=[O:22]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 178444367HCID 178444367, compound

Product 1

HCID 178444368HCID 178444368, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 10 g of 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-benzonitrile and 20 g of KOH in 40 ml of water and 160 ml of ethanol is boiled for 16 hours, cooled and worked up in the usual manner to give 2,6-difluoro-4-(trans-4-pentylcyclohexyl)-benzoic acid.

Workup

  1. temperaturecooled

Sources & evidence

ORD record
ord-fd844f6af06246e1be2ce9e5ccce25a4
Source dataset
uspto-grants-1985_11
Patent number
US04551264

Reaction notes

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