Methanol → HCID 10465243, compound

Participants

Reaction Steps

One equivalent of lithium hydroxide monohydrate was added to a solution of dimethyl-5-aminoisophthalate (prepared from 5-aminoisophthalic acid, thionyl chloride and methanol) in methanol (75 ml) and water (20 ml) and stirred at room temperature for 24 hours. The cloudy solution was heated for 2 hours on a hot plate and stripped of methanol on a rotary evaporator. The residue was triturated with hydrochloric acid and then extracted into methylene chloride (2×75 ml). The combined methylene chloride extracts were dried over sodium sulfate, filtered and stripped of solvent. The material was purified by crystallization from methanol-ethyl ether. m.p. 214°-220° C.

Provenance & Evidence