Methanol → HCID 86740490, compound

Participants

Reaction Steps

The material from Example 67 was treated with methyl alcohol (300 ml), lithium hydroxide monohydrate (6.3 g) and water (100 ml) and stirred for about 18 hrs. at room temperature. After warming on a hot plate for 6 hrs. and allowing to stir ovrnight at room temperature, the methyl alcohol was removed on a rotary evaporator and the aqueous residue acidified with 1N hydrochloric acid to pH 2. The product was extracted into ethyl acetate (2×100 ml), dried over sodium sulfate, filtered and stripped of solvent to yield an oil. The title compound was purified by chromatography on silica gel.

Provenance & Evidence