Chloromethyl Methyl Ether → HCID 18600045, compound

HRID 1583263Notes

Reaction equation

HRID 1583263 reaction equation
[CH3:1][O:2][C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH2:11][C:12]2=[C:22]([N+:33]#[C-:34])[S:23]([C:26]2[CH:31]=[CH:30][C:29]([CH3:32])=[CH:28][CH:27]=2)(=[O:25])=[O:24])[CH:4]=1.Cl[CH2:36][O:37][CH3:38]>>[CH3:1][O:2][C:3]1[CH2:20][CH2:19][C@@:18]2([CH3:21])[C:5](=[CH:6][CH2:7][C@@H:8]3[C@@H:17]2[CH2:16][CH2:15][C@@:13]2([CH3:14])[C@H:9]3[CH2:10][CH:11]=[C:12]2[C:22]([N+:33]#[C-:34])([S:23]([C:26]2[CH:27]=[CH:28][C:29]([CH3:32])=[CH:30][CH:31]=2)(=[O:25])=[O:24])[CH2:36][O:37][CH3:38])[CH:4]=1

Participants

3

Reactant 2

HCID 7864Chloromethyl Methyl EtherHCID 53955656HCID 53955656, compound

Product 1

HCID 18600045HCID 18600045, compound

Procedure

The title compound was prepared according to the process described in Example 8a, starting with 3-methoxy-17-(isocyano-p-methylphenylsulfonylmethylene)-androsta-3,5-diene (477 mg, 1 mmol) and chloromethylmethylether (0.2 ml). Yield: 385 mg.

Sources & evidence

ORD record
ord-c0d257ecd78b40fbade4d403d4e0ff17
Source dataset
uspto-grants-1985_11
Patent number
US04551278

Reaction notes

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