Phosphorus oxychloride → 5-tert-butyl-7-chloro[1,2,4]triazolo[1,5-a]pyrimidine

Participants

Reaction Steps

A mixture of 20 g of 4-hydroxy-6-t-butyl-1,3,3a,7-tetrazaindene and 80 ml of phosphorus oxychloride was refluxed for 3 to 4 hours at a temperature kept at 140° to 150° C. by means of an oil bath. After excess phosphorus oxychloride was distilled away under reduced pressure, the reaction mixture was poured into ice water. The reaction product was extracted with methylene chloride and dried over anhydrous sodium sulfate. After the removal of methylene chloride by distillation, pale yellow crystals were obtained. Yield 16 g.

Provenance & Evidence