5-(2,4-dichlorophenyl)-N-[4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine → N-[4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)-3-pyridinyl]pyrazin-2-amine

HRID 158336Notes

Reaction equation

HRID 158336 reaction equation
[CH2:33]([CH3:34])[O:35][CH:36]1[CH:37]([NH:41][c:42]2[n:43][c:44]([CH2:62][CH3:63])[c:45](-[c:50]3[c:51]([C:58]([F:59])([F:60])[F:61])[n:52][c:53]([O:56][CH3:57])[cH:54][cH:55]3)[n:46][c:47]2[CH2:48][CH3:49])[CH2:38][NH:39][CH2:40]1.[Cl:1][c:2]1[cH:3][c:4]([Cl:5])[cH:6][cH:7][c:8]1-[c:9]1[n:10][c:11]([CH2:12][CH3:13])[c:14]([NH:15][CH:16]2[CH:17]([O:18][CH2:19][CH3:20])[CH2:21][N:22]([c:26]3[s:27][cH:28][cH:29][n:30]3)[CH2:23]2)[n:24][c:25]1[CH2:31][CH3:32]>>[c:26]1([N:39]2[CH2:38][CH:37]([NH:41][c:42]3[n:43][c:44]([CH2:62][CH3:63])[c:45](-[c:50]4[c:51]([C:58]([F:59])([F:60])[F:61])[n:52][c:53]([O:56][CH3:57])[cH:54][cH:55]4)[n:46][c:47]3[CH2:48][CH3:49])[CH:36]([O:35][CH2:33][CH3:34])[CH2:40]2)[s:27][cH:28][cH:29][n:30]1

Participants

3

Reactant 2

HCID 731004855-(2,4-dichlorophenyl)-N-[4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amineHCID 178467178N-(4-ethoxypyrrolidin-3-yl)-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)-3-pyridinyl]pyrazin-2-amine

Product 1

HCID 72968131N-[4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethyl-5-[6-methoxy-2-(trifluoromethyl)-3-pyridinyl]pyrazin-2-amine

Sources & evidence

ORD record
ord-5a8409b0287b4721a0f47614a24fff89
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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