Dimethylformamide → N-(4-1H-Imidazol-1-yl)butyl-2-(1-methylethyl)-11-oxo-11H-pyrido(2,1b)quinazoline-8-carboxamide

Participants

Reaction Steps

A solution of 1.30 g of cyanomethyl 2-(1-methylethyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylate and 1.20 g of (1H-imidazol-1-yl)butanamine in 15 ml of dimethylformamide was stirred at a bath temperature of 35° C. for 18 hours. The reaction mixture was diluted with water and the crude precipitate was recrystallized from acetonitrile to give 1.41 g (85%) of N-[4-(1H-imidazol-1-yl)butyl]-2-(1-methylethyl)-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxamide, mp 165°-167° C.

Provenance & Evidence