HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 3-(Pyridin-3-yl)propan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-[3-(Pyridin-3-yl)propyl]-1H-isoindole-1,3(2H)-dione | HCID 13557552 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Pyridin-3-yl)propan-1-amine | HCID 13557523 | 82.5% |
Reaction Steps
A mixture of 11.3 g of 2-[3-(3-pyridyl)propyl]-1H-isoindole-1,3(2H)-dione and 10.1 g of hydrazine hydrate was refluxed in 200 ml of ethanol for 6 hours, allowed to cool, and was filtered. The filtrate was concentrated and the residue distilled to give 4.77 g (70%) of 3-pyridinepropanamine, bp 84°-86° C./0.35 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04551460 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-fcbc6f61b72c42cc80c77c5ac8c63246 |
| Source note | uspto-grants-1985_11 |