4-(3-Bromopropyl)pyridine → 4-(Pyridin-4-YL)butanenitrile

HRID 1583399Notes

Reaction equation

HRID 1583399 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](CCCC#N)[CH:2]=1.[N:12]1C=[CH:16][C:15](CCCBr)=[CH:14][CH:13]=1>>[N:1]1[CH:2]=[CH:3][C:4]([CH2:16][CH2:15][CH2:14][C:13]#[N:12])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 127470564-(3-Bromopropyl)pyridineHCID 135575244-(Pyridin-3-yl)butanenitrile

Product 1

HCID 135575314-(Pyridin-4-YL)butanenitrileYield 51%

Procedure

4-Pyridinebutanenitrile was prepared according to the procedure employed in the synthesis of 3-pyridinebutanenitrile. From 73.1 g of the hydrobromide salt of 3-(4-pyridyl)propyl bromide there was obtained 19.35 g (51%) of 4-pyridinebutanenitrile, bp 140°-141° C./2.0 mm.

Workup

  1. custom4-Pyridinebutanenitrile was prepared

Sources & evidence

ORD record
ord-3d9c6b16619c4c32aaa22dcaaf800499
Source dataset
uspto-grants-1985_11
Patent number
US04551460

Reaction notes

Loading…