2-Bromoethylamine hydrobromide → HCID 20260597, compound

Participants

Reaction Steps

A solution of 32.72 g of 4-mercaptopyridine and 61.0 g of 2-bromoethanamine hydrobromide in 200 ml of absolute ethanol was heated to reflux under an argon atmosphere for 2 hours. After cooling the precipitated product was collected and washed with ethanol to give 76.31 g of crude 2-(4-pyridylthio)ethanamine dihydrobromide, mp 250°-254° C. Recrystallization from ethanol (1500 ml) and water (150 ml) with a charcoal treatment afforded 63.09 g (68%) of 2-(4-pyridylthio)ethanamine dihydrobromide, mp 265°-268° C.

Provenance & Evidence