HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 7-(Pyridin-3-yl)heptan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-[7-(Pyridin-3-yl)heptyl]acetamide | HCID 13557529 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 7-(Pyridin-3-yl)heptan-1-amine | HCID 13557530 | 81.2% |
Reaction Steps
A solution of 5.1 g of N-[7-(3-pyridyl)heptyl]acetamide was heated to reflux in diluted hydrochloric acid overnight. The mixture was cooled, made basic with 50% sodium hydroxide solution and was extracted with dichloromethane. The combined organic layers were dried over potassium carbonate and were evaporated. The residue was distilled to give 3.4 g of 3-pyridine heptanamine, bp 175°-180° C./0.4 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04551460 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-3805197ade654298a29bb3b30b38035f |
| Source note | uspto-grants-1985_11 |