Hydrochloric Acid → HCID 13557563, compound

Participants

Reaction Steps

A solution of 8.3 g of 5-(1H-imidazol-1-yl)-2-pentanone, 44.0 g of ammonium acetate, and 3.5 g of sodium cyanoborohydride in 200 ml of methanol was stirred at room temperature for 2.5 days. The reaction mixture was acidified with hydrochloric acid and concentrated to dryness. The residue was taken up in potassium carbonate solution and extracted with dichloromethane. The combined extracts were dried over potassium carbonate and evaporated and the residue was distilled to give 4.6 g (55%) of alphamethyl-1H-imidazole-1-butanamine, bp 110°-117° C./0.25 mm.

Provenance & Evidence