HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 6-(Quinolin-3-yl)hexan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-[6-(Quinolin-3-yl)hexyl]-1H-isoindole-1,3(2H)-dione | HCID 13557555 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-(Quinolin-3-yl)hexan-1-amine | HCID 13557548 | 89.2% |
Reaction Steps
3-Quinolinehexanamine was prepared in the same manner as described in Example 110, starting from 4.4 g of 2-[6-(3-quinolinyl)hexyl]-1H-isoindole-1,3(2H)-dione and 2.5 g of hydrazine hydrate in 60 ml of ethanol. The crude product was evaporatively distilled to give 2.5 g (89%) of 3-quinolinehexanamine, bp 144°-155° C./0.1 mm. Bis picrate mp 225°-226° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04551460 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-21745a1fab1441a99373208ceaf63d74 |
| Source note | uspto-grants-1985_11 |