Potassium Permanganate → 6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one

HRID 1583467Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH2:7][CH2:6][C@:5]2(NC(N)=O)C(O)=O.[Mn]([O-])(=O)(=O)=[O:20].[K+]>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][CH2:7][CH2:6][C:5]2=[O:20]

Participants

Reactant 2

HCID 516875Potassium Permanganate

HCID 13298580HCID 13298580, compound

Product 1

HCID 27332626-fluoro-2,3-dihydro-4H-1-benzopyran-4-one

Procedure

The title compound can be prepared by oxidation of (R)-6-fluoro-4-ureidochroman-4-carboxylic acid with potassium permanganate, using the procedure of Example 1.

Sources & evidence

ORD record: ord-20116ecca6d94cc7a1241c17cf1f99a7
Source dataset: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04551542

Reaction notes

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