反应详情

To the solution of 3-(benzyloxycarbonylamino)-N-(2-bromoethyl)propionamide (10.0 g, 0.03 mol) in acetone (250 ml), acetone (100 ml) solution of potassium thiobenzoate (5.35 g, 0.03 mol) is added. The mixture is stirred for 1 hour and insoluble substance is filtered off. The filtrate is concentrated in vacuo and the residue is dissolved in chloroform. The solution is washed with sodium hydroxide solution, water and then saturated sodium chloride solution, and dried over anhydrous magnesium sulfate. The solution is concentrated in vacuo to give 7.9 g (68%) of the titled compound.

1. filtrationinsoluble substance is filtered off
2. concentrationThe filtrate is concentrated in vacuo
3. dissolutionthe residue is dissolved in chloroform
4. washThe solution is washed with sodium hydroxide solution, water
5. dry with materialsaturated sodium chloride solution, and dried over anhydrous magnesium sulfate
6. concentrationThe solution is concentrated in vacuo