Hydrochloric Acid → HCID 20259029, compound

Participants

Reaction Steps

A stirred mixture of 4-[(5-bromo-2-thienyl)carbonyl]-5-methyl-1,3-dihydro-2H-imidazol-2-one (10 grams, 0.034 mole), cuprous cyanide (3.0 grams, 0.034 mole) and dimethylformamide (150 ml) are refluxed for 4 hours. The resulting mixture is poured into a solution of 200 grams ferric chloride and 50 ml concentrated hydrochloric acid in 300 ml water. After the reaction mixture is maintained at 60°-70° C. for 20 minutes, the layers were separated. The aqueous layer is extracted with toluene and the combined organic layers are washed with water and dried. Evaporation of solvent gives the title compound which is recrystallized from methanol.

Provenance & Evidence