2,5-Dimethoxytetrahydrofuran → HCID 20259059, compound

Participants

Reaction Steps

4.6 Grams of 1-ethyl-1,4-dihydro-4-oxo-7-amino-1,8-naphthyridine-3-carboxylic acid (U.S. Pat. No. 3,149,104) and 2.7 grams of 2,5-dimethoxytetrahydrofuran are placed under reflux for 30 minutes in 70 ml of glacial acetic acid. The mixture is allowed to cool then left for 8 hours at 5° C., and a precipitate is obtained which, when filtered off and recrystallized in acetonitrile, gives 4.3 grams of needles, of melting point 230°-232° C.

Provenance & Evidence