反应详情

温度

50 °C

A mixture consisting of 2.0 g of 3-(2-fluoroethoxy)benzyl chloride, 2.3 g of 2-(4-chlorophenyl)-2-methylpropyl alcohol, 0.5 g of triethylbenzylammonium bromide and 5 g of a 50% aqueous solution of sodium hydroxide was stirred at 50° C. for 2 hours. The reaction mixture was cooled to room temperature, and poured into water. Toluene was added, and the mixture was fully stirred. The toluene layer was separated, washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure. The resulting crude ether was purified by silica gel (100 g) column chromatography (developing solvent: toluene) to give 2.9 g of the desired 3-(2-fluoroethoxy)benzyl 2-(4-chlorophenyl)-2-methylpropyl ether.

1. temperatureThe reaction mixture was cooled to room temperature
2. stirringthe mixture was fully stirred
3. customThe toluene layer was separated
4. washwashed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customToluene was evaporated under reduced pressure
7. customThe resulting crude ether was purified by silica gel (100 g) column chromatography (developing solvent: toluene)