反应详情

温度

50 °C

A mixture composed of 1.0 g of 4-chlorophenoxychloromethane, 1.0 g of 4-(2-fluoroethoxy)benzyl alcohol, 0.3 g of triethylbenzylammonium bromide and 20 g of a 50% aqueous solution of sodium hydroxide was stirred at 50° C. for 1.5 hours. The reaction mixture was cooled to room temperature, and poured into water. Toluene was added, and the mixture was fully stirred. The toluene layer was separated, washed with water, and dried over anhydrous sodium sulfate. Toluene was evaporated. The resulting crude ether was recrystallized from benzene to give 1.18 g of the desired 4-(2-fluoroethoxy)benzyl 4-chlorophenoxymethyl ether.

1. temperatureThe reaction mixture was cooled to room temperature
2. stirringthe mixture was fully stirred
3. customThe toluene layer was separated
4. washwashed with water
5. dry with materialdried over anhydrous sodium sulfate
6. customToluene was evaporated
7. customThe resulting crude ether was recrystallized from benzene