反应详情

Raney nickel (1.5 kg) was added to a solution of 214 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 3 l of ethanol and the mixture was refluxed for 3 hours. After completion of reaction the reaction mixture was cooled and Raney nickel was removed by filtration. Concentration of the filtrate gave 101 g of 2-methyl-4-morpholino-5-fluoroindole.

1. temperaturethe mixture was refluxed for 3 hours
2. customAfter completion of reaction the reaction mixture
3. temperaturewas cooled
4. customRaney nickel was removed by filtration