HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoro-7-bromoindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole | HCID 20258982 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Methyl-4-morpholino-5-fluoro-7-bromoindole | HCID 20258993 | 65.3% |
Reaction Steps
Raney nickel (400 g) was added to a solution of 58 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 1 l of dioxane and the mixture was allowed to react at room temperature for 4 hours. After completion of the reaction Raney nickel was removed by filtration, and the filtrate was concentrated under reduced pressure. 33 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04552879 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-78b4bffbaf9d43c7b1f4e011992d8ec7 |
| Source note | uspto-grants-1985_11 |