HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzophenone oxime → Gamma-Butyrolactone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzophenone oxime | HCID 11324 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 14989418 | HCID 14989418 | — |
| Reactant | HCID 15341864 | HCID 15341864 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Gamma-Butyrolactone | HCID 7302 | — |
| Product | HCID 20259730 | HCID 20259730 | — |
Reaction Steps
The synthesis of 4-aminooxybutyric acid and 5-aminooxyvaleric acid are described in Tetrahedron, 23, 4441 (1967). Benzophenone oxime in N-methylpyrrolidone is reacted first with sodium then with γ-butyrolactone to provide N-diphenylmethylidene-4-aminooxybutyric acid which is subsequently hydrolyzed to form 4-aminooxybutyric acid. 5-aminooxyvaleric acid hydrochloric acid salt is prepared similarly by substituting γ-butyrolactone with σ-valerolactone. Aminooxyacetic acid is available as the hemihydrochloride from a commercial source.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04552898 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-b7624ec010124bcd836b1c22b6658a80 |
| Source note | uspto-grants-1985_11 |