2-Chloro-N,N-dimethylethylamine → N-carbobenzyloxy-gamma-tert.butyl-L-glutamic acid-alpha-dimethylaminoethyl ester

HRID 1583667Notes

Reaction equation

HRID 1583667 reaction equation
C1([NH2+]C2CCCCC2)CCCCC1.[C:14]([NH:24][C@H:25]([C:35]([O-:37])=[O:36])[CH2:26][CH:27]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([O-:30])=[O:29])([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].C1([NH2+]C2CCCCC2)CCCCC1.[CH3:51][N:52]([CH2:54][CH2:55]Cl)[CH3:53]>>[CH3:51][N:52]([CH3:53])[CH:54]([O:36][C:35](=[O:37])[C@H:25]([CH2:26][CH:27]([C:31]([CH3:32])([CH3:33])[CH3:34])[C:28]([OH:30])=[O:29])[NH:24][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[CH3:55]

Participants

3

Reactant 2

HCID 79012-Chloro-N,N-dimethylethylamineHCID 131714411N-carbobenzyloxy-gamma-tert.butyl-L-glutamic acid-dicyclohexyl ammonium salt

Product 1

HCID 56633880N-carbobenzyloxy-gamma-tert.butyl-L-glutamic acid-alpha-dimethylaminoethyl ester

Procedure

that N-carbobenzyloxy-γ-tert.butyl-L-glutamic acid-dicyclohexyl-ammonium salt as starting material is reacted with dimethylaminoethylchloride to form N-carbobenzyloxy-γ-tert.butyl-L-glutamic acid-α-dimethylaminoethyl ester,

Sources & evidence

ORD record
ord-1ffff93bd8e947c4874b4090b3e3d59a
Source dataset
uspto-grants-1985_11
Patent number
US04552975

Reaction notes

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