HRID1583668

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID407726

未命名化合物

结构：C1CCC([NH2+]C2CCCCC2)CC1.C1CCC([NH2+]C2CCCCC2)CC1.CC(C)(C)C(C[C@H](NC(=O)OCc1ccccc1)C(=O)[O-])C(=O)[O-]

HCID131714411

未命名化合物

PRODUCTS

生成物

结构：CN(C)CCOC(=O)[C@H](CC(C(=O)O)C(C)(C)C)NC(=O)OCc1ccccc1

HCID56625707

未命名化合物

HCID69082364

未命名化合物

PROCEDURE

实验过程

In said first step, N-carbobenzyloxy-γ-tert.butyl-L-glutamic acid-dicyclohexyl ammonium salt suspended in the organic solvent is reacted with dimethyl-aminoethylchloride in the solution to form N-carbobenzyloxi-γ-tert.butyl-L-glutamic acid-dimethylaminoethyl ester (Intemediate I) and dicyclohexyl-ammonium chloride to be precipitated.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1f2a292f06c24b129509cbfacf666801
来源数据集: uspto-grants-1985_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04552975
来源说明: uspto-grants-1985_11

反应 SMILES

[CH:1]1([NH2+:7][CH:8]2[CH2:13]CCCC2)CCCCC1.[C:14]([NH:24][C@H:25]([C:35]([O-:37])=[O:36])[CH2:26][CH:27]([C:31]([CH3:34])([CH3:33])[CH3:32])[C:28]([O-:30])=[O:29])([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].[CH:38]1([NH2+:44][CH:45]2[CH2:50][CH2:49][CH2:48][CH2:47][CH2:46]2)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1.CC(C)(N)C[Cl:54]>>[CH3:38][N:7]([CH2:8][CH2:13][O:36][C:35](=[O:37])[C@H:25]([CH2:26][CH:27]([C:31]([CH3:32])([CH3:33])[CH3:34])[C:28]([OH:30])=[O:29])[NH:24][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[CH3:1].[Cl-:54].[CH:45]1([NH2+:44][CH:38]2[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]2)[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]1