Dimethylformamide → HCID 13749972, compound

Participants

Reaction Steps

500 mg of succinic anhydride was added to a solution of 500 mg of alanyl proline ethylamide in form of dioxane (10 ml) and 0.25 ml of dimethylformamide and the reaction solution heated under reflux for 30 minutes. Then the solution was evaporated and the residue crystallized from 10 ml of acetone and 30 ml of ether. 510 mg of a product having a melting point of 139 to 141 degrees C. was obtained. [α[D20 -129.2 degrees (c 0.3; 50% methyl alcohol).

Provenance & Evidence