Ammonia → HCID 10087900, compound

Participants

Reaction Steps

40 grams of 2-amino-3-carbethoxyamino-6-(2,4,6-trimethylbenzylamino)-pyridine hydrochloride were dissolved in 200 ml of methanol and treated with 25% aqueous ammonia, whereupon the base crystallized out. The base was filtered off with suction and dissolved in dioxane/methanol (2:1 by volume) in the hot. The warm solution was acidified with a solution of citric acid in methanol to pH 3, whereupon the "citrate" precipitated in cooling with stirring. The compound crystallized with 0.33 mole of citric acid and was recrystallized from a little isopropanol.

Provenance & Evidence