Water → HCID 19834616, compound

Participants

Reaction Conditions

Reaction Steps

0.1 mol (30.45 g) of β-chloroethyl 2-nitro-4-(β-hydroxyethoxy)-phenylcarbamate is introduced into 62 ml of water. 10 ml of 10N sodium carbonate solution are added gradually in the course of a few minutes, whilst stirring. The temperature rises to about 60° C. The temperature of the reaction medium is then raised to 70° C. and 22 ml of 10N sodium carbonate solution are then added, whilst stirring. Stirring is continued for 15 minutes at 70° C. After cooling, the desired product is filtered off; after washing with water, drying and recrystallisation from methanol, it melts at 82° C.

Provenance & Evidence