反应详情

8.1 parts of sodium hydroxide were dissolved in 100 parts by volume of water and the solution cooled to 0°-5° C. 13.3 parts of L-aspartic acid were added and stirred until all dissolved, then 15.8 parts by volume of diketene were added dropwise over 90 minutes, stirred at 0°-10° C. for an additional 2.5 hours, and filtered. The homogeneous solution was evaporated to dryness under vacuum at 35°-40° C. Disodium N-acetoacetylaspartate was obtained as a white foam.

1. temperaturethe solution cooled to 0°-5° C
2. stirringstirred at 0°-10° C. for an additional 2.5 hours
3. filtrationfiltered
4. customThe homogeneous solution was evaporated to dryness under vacuum at 35°-40° C