反应详情

2.84 g of N-[6-(2,4-difluorophenoxy)-1-hydroxy-5-indanyl]methanesulfonamide and 1.83 g of phosphorus pentachloride are stirred in 50 ml of dichloromethane-diethyl ether (1:1) for 45 minutes at 0° C. At 0° C., a solution of 7 g of dimethylamine in 25 ml of dichloromethane is added to the reaction mixture. After 2 hours at 20° C. and 20 minutes of boiling, the mixture is concentrated and the residue is recrystallized from aqueous hydrochloric acid, yielding 2.41 g of N-[6-(2,4-difluorophenoxy)-1-dimethylamino-5-indanyl]methanesulfonamide, hydrochloride, mp 195° C.

1. custom20 minutes
2. concentrationthe mixture is concentrated
3. customthe residue is recrystallized from aqueous hydrochloric acid