Sodium borohydride → N-[6-(2,4-difluorophenoxy)1-hydroxy-5-indanyl]methanesulfonamide

Participants

Reaction Steps

2.13 g of 6-(2,4-difluorophenoxy)-5-methylsulfonylamino-3-phenyl-1-indanone is dissolved in 20 ml of methanol and 5.5 ml of 1N sodium hydroxide solution. At 0° C., 400 mg of sodium borohydride is added to the mixture. After 16 hours at 20° C., the mixture is concentrated, combined with water, neutralized with 1N sulfuric acid, and vacuum-filtered, thus obtaining 1.7 g of N-[6-(2,4-difluorophenoxy)1-hydroxy-5-indanyl]methanesulfonamide, mp 119° C.

Provenance & Evidence