Toluene → N-[5-tert-Butyl-4-(hexadecyloxy)-2-hydroxyphenyl]acetamide

Participants

Reaction Steps

A mixture of 30.0 g of 2-acetylamino-5-hexadecyloxyphenol obtained in Synthesis Example 3, 20.0 g of Amberlyst 15 (produced by Rohm & Haas, Co., U.S.A.) and 300 ml of toluene was stirred while heating at 80° to 90° C. during which isobutene was bubbled therethrough for 5 hours. The reaction solution was filtered to remove solids and the filtrate was condensed. On adding 350 ml of n-hexane to the residue, crystals precipitated. The crystals were collected by filtration. 23.5 g of 2-acetylamino-4-tert-butyl-5-hexadecyloxyphenol was obtained.

Provenance & Evidence