Potassium Hydroxide → HCID 18610592, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 0.7 g of 21-acetoxy-17α-ethoxymethoxy-11β-hydroxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione in 8 ml of a 0.2N methanolic potassium hydroxide solution is stirred for 30 minutes at 0° C. and thereafter neutralized with 10% strength acetic acid. After performing the usual working-up steps, 470 mg of 17α-ethoxymethoxy-11β,21-dihydroxy-6α,16β-dimethyl-1,4-pregnadiene-3,20-dione is isolated, mp 100°-102° C.

Provenance & Evidence