HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichromate ion → N-[N2-(1(S)-carboxy-3-phenylpropyl)-N6-carbamoylmethyl-L-lysyl]-L-proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichromate ion | HCID 24503 | — |
| Reactant | 2-Hydroxyacetamide | HCID 69021 | — |
| Reactant | Lisinopril | HCID 5362119 | — |
| Reactant | 2-oxoacetamide | HCID 11708045 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | N-[N2-(1(S)-carboxy-3-phenylpropyl)-N6-carbamoylmethyl-L-lysyl]-L-proline | HCID 86740515 | — |
Reaction Steps
In the manner described above in Example 1, N-[N2 (1(S)-carboxy-3-phenylpropyl)-L-lysyl]-L-proline and glyoxylic acid amide (which can be prepared by the oxidation of glycolamide with pyridinum dichromate) were hydrogenated in the presence of 10% Pd on carbon catalyst to yield N-[N2 -(1(S)-carboxy-3-phenylpropyl)-N6 -carbamoylmethyl-L-lysyl]-L-proline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04555503 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-1358a9d2be3f4fc4960233821e9749b9 |
| Source note | uspto-grants-1985_11 |