HCID 13206063, compound → HCID 20257386, compound

Participants

Reaction Steps

6.5 g of Ethyl 2-[3-chloro-4-(1,1-dimethyl-2-propynylamino)phenyl]propionate (Compound 1) was dissolved in 70 ml of dioxane, and 10.0 g of zinc chloride were added thereto. The mixture was reacted at 95° C. for 15 hours under nitrogen atmosphere. After the reaction, the mixture was diluted with 100 ml of hexane, and subjected to column chromatography on silica gel. The solvent was distilled off to give 6.1 g of Ethyl 2-(8-chloro-1,2-dihydro-2,2-dimethylquinolin-6-yl)propionate (Compound 6).

Provenance & Evidence