Ethanol → HCID 20257391, compound

Participants

Reaction Steps

3.7 g of methyl 2-(1-allyl-1,2-dihydro-2,2-dimethylquinolin-6-yl)propionate (Compound 20) was added to ethanol. Palladium-on-carbon was further added to the solution, and the mixture were reacted with stirring at room temperature for 20 hours under atmospheric pressure in hydrogen atmosphere. After the catalyst was filtered off, the filtrate was concentrated, and then purified by column chromatography on silica gel (ether:hexane=1:4) to give 3.0 g of methyl 2-(1,2,3,4-tetrahydro-2,2-dimethyl-1-propylquinolin-6-yl)propionate (Compound 14).

Provenance & Evidence