Sodium Hydroxide → HCID 13206065, compound

Participants

Reaction Steps

3.0 g of ethyl 2-(8-chloro-1,2-dihydro-1,2,2-trimethylquinolin-6-yl)propionate (Compound 18) were added to a mixture of 40 ml of ethanol and 10% aqueous solution of sodium hydroxide. The solution was heated and refluxed for 4 hours. Ethanol was distilled off and the reaction mixture was diluted with water and washed with ether. The water layer was made weakly acidic by the addition of hydrochloric acid, and then extracted with ethyl acetate. The organic layer was washed with water and saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was recrystallized from hexane to give 2.3 g of 2-(8-chloro-1,2-dihydro-1,2,2-trimethylquinolin-6-yl)propionic acid (Compound 34).

Provenance & Evidence