Hydrochloric Acid → HCID 70456445, compound

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A solution of 4-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (6.0 g) in concentrated hydrochloric acid (10 ml) was heated at 100° C. for 8 hours and then evaporated to give an oil which solidified on trituration with ethyl acetate. The solid was crystallised twice from aqueous acetonitrile to give 4-(1-imidazolylmethyl)phenoxyacetic acid hydrochloride (4.84 g), m.p. 107°-110° C. Found: C, 50.24, H, 5.31, N, 9.83. C12H12N2O3.HCl.H2O requires: C, 50.28, H, 5.23, N, 9.77%.

Provenance & Evidence