Trifluoroacetic acid → HCID 53789842, compound

Participants

Reaction Steps

N-[N5 -(N-Cbz-glycyl)-L-ornithyl]-L-proline was prepared as described in Example 4. The reductive alkylation of TFA salt (132 mg, 0.314 mmol) with ethyl 2-oxo-4-phenylbutyrate (324 mg, 1.57 mmol) and sodium cyanoborohydride (59.2 mg, 0.942 mmol) was carried out in the usual manner. The work up, including 30-32% HBr/HOAc treatment, was the same as that described in Example 1. Both ms and nmr were consistent with the structure for N-[N2 -(1-ethoxycarbonyl-3-phenylpropyl)-N5 -glycyl-L-ornithyl]-L-proline (47.5 mg).

Provenance & Evidence