Tetrahydrofuran → HCID 20257593, compound

Participants

Reaction Steps

A mixture of 2.36 g of 6-chloronicotinic acid and 2.43 g of 1,1'-carbonyldiimidazole in 60 ml of tetrahydrofuran was stirred at room temperature for 2 hours. Then, 2.08 g of 2-methyl-1H-imidazolepropanamine was added and the mixture was stirred at room temperature for 48 hours. The white precipitate which formed on the walls of the flask was collected by filtration, washed with ether and gave 3.2 g of the compound of the Example as cream colored crystals, mp 175°-177° C.

Provenance & Evidence