Sodium Hydroxide → HCID 178493216, compound

Participants

Reaction Steps

A mixture of 8.5 ml of commercially available sodium hypochlorite solution (about 15% of active chlorine) and 6 ml of 10% strength sodium hydroxide solution is added dropwise to a solution of 1.5 g 2-[(4-methoxy-2-pyridyl)methylthio]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole in 30 ml of ethyl acetate at 0° C. in the course of 20 min., stirring is continued at this temperature for 20 min. and 0.6 ml of 10% strength sodium thiosulfate solution is then added. 1.5 g of ammonium sulfate are added and the organic phase is separated off, washed with saturated sodium chloride solution, dried with magnesium sulfate and concentrated to a small volume. 1.3 g (85%) of the title compound of melting point 131°-132° C. (decomposition) are obtained by precipitation with diisopropyl ether.

Provenance & Evidence