Acetic Acid → HCID 13563837, compound

Participants

Reaction Steps

A solution of 0.20 g (0.52 mmol) of 5-[[(4-decyl-2-pyridinyl)carbonyl]amino]pentanoic acid, ethyl ester prepared in Example 7, 0.05 g (1 mmol, 2 eq) of LiOH·H2O in 4 ml of THF and 1 ml of H2O was stirred at room temperature for 21 hours, then 1.5 eq of glacial acetic acid was added. The resulting solution was poured into H2O and extracted with Et2O. The organic layers were combined, poured into H2O and extracted with Et2O. The organic layers were combined, dried (Na2SO4) and concentrated in vacuo. Hexanes were added to the residue and the flask was cooled. The resulting white solid was collected, yielding 180 mg (97%) of title compound: m.p. 54°-56° C.

Provenance & Evidence