Potassium cyanate → HCID 178433510, compound

HRID 1584023Notes

Reaction equation

HRID 1584023 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:5]=1[NH2:11])=O.[O-:12][C:13]#[N:14].[K+]>>[F:10][C:8]1[CH:9]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:11][C:13](=[O:12])[N:14]=[C:2]2[CH3:1]

Participants

3

Reactant 2

HCID 11378442Potassium cyanateHCID 135635321-(2-Amino-5-fluorophenyl)ethan-1-one

Product 1

HCID 178433510HCID 178433510, compound

Procedure

6-Fluoro-4-methyl-2(1H)-quinazolinone is prepared by treatment of 2-amino-5-fluoroacetophenone with potassium cyanate as in Example 18 and is isolated as the 1/4 hydrate, (mp 294°-296° C.).

Sources & evidence

ORD record
ord-1980041ef83647ed8eedfca118d6a952
Source dataset
uspto-grants-1985_11
Patent number
US04555571

Reaction notes

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